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Comment on "A common genetic variant is associated with adult and childhood obesity".

Loos RJ, Barroso I, O'rahilly S, Wareham NJ

Medical Research Council Epidemiology Unit, Cambridge, UK. ruth.loos@mrc-epid.cam.ac.uk

Herbert et al. (Reports, 14 April 2006, p. 279) found that the rs7566605 genetic variant, located upstream of the INSIG2 gene, was consistently associated with increased body mass index. However, we found no evidence of association between rs7566605 and body mass index in two large ethnically homogeneous population-based cohorts. On the contrary, an opposite tendency was observed.

Published 12 January 2007 in Science, 315(5809): 187; author reply 187.
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