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Comment on "A common genetic variant is associated with adult and childhood obesity".

Rosskopf D, Bornhorst A, Rimmbach C, Schwahn C, Kayser A, Krüger A, Tessmann G, Geissler I, Kroemer HK, Völzke H

Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany. dieter.rosskopf@uni-greifswald.de

Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.

Published 12 January 2007 in Science, 315(5809): 187; author reply 187.
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